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Evidence-Based Supplement Research

Evidence-Based Supplement Research

bifidobacterium longum and Reduced Blood Cholesterol

Safety in these studies

Overall tolerabilityReported
While generally safe in healthy populations, rare adverse events (bacteremia, D-lactic acidosis, horizontal gene transfer) have been reported in immunocompromised or critically ill individuals, underscoring the need for individualized risk-benefit assessments and rigorous adverse-event surveillance.
from: Molecular Pathways and Clinical Applications of Probiotics as Effective Supporters of Inte

1 of 1 paper

Molecular Pathways and Clinical Applications of Probiotics as Effective Supporters of Intestinal, Neurologic, and Cardiovascular Health: a Narrative Review.
- 2026-11
- Review
- The Journal of nutritional biochemistry 157
- - Álvaro Vergara A Nieto
  - Andrés Halabi Diaz
  - Millaray Hernández Millán
  - Daniel Sagredo
  - Javier Arriagada Gacitua
- PubMed: 42177952
- DOI: 10.1016/j.jnutbio.2026.110424
10 Insights on
- Reduced Blood Cholesterol
- Low evidence
Meta-analyses of 30+ RCTs demonstrate that probiotic supplementation (notably L. acidophilus, L. plantarum, B. longum) lowers total and LDL cholesterol (-7 to -10 mg/dL)
Effect
Beneficial
Effect size
Small
Significant
Yes