Bitter Melon and Improved Fasting Plasma Glucose

• Bitter gourd (Momordica charantia L.) supplementation for twelve weeks improves biomarkers of glucose homeostasis in a prediabetic population.

  • 2025-05
  • RCT · n = 38
  • Journal of ethnopharmacology 347
  • • Jurriaan J Mes
    • Maartje van den Belt
    • Sandra van der Haar
    • Els Oosterink
    • Teus Luijendijk
    • Koen Manusama
    • Lotte van Dam
    • Tessa de Bie
    • Renger Witkamp
    • Diederik Esser

  • PubMed: 40199408
  • DOI: 10.1016/j.jep.2025.119756

  3 Insights on

  • Improved Fasting Plasma Glucose

  • High evidence
  • Clinical

  significant reductions of FPG (p = 0.014), fasting insulin (p = 0.007), and HOMA-IR (p = 0.003) after a 12-week intervention with the bitter gourd supplement.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  3.6 g/day