Bovine Colostrum and Reduced Periventricular Leukomalacia

• Bovine colostrum to supplement the first feeding of very preterm infants: The PreColos randomized controlled trial.

  • 2023-08
  • RCT · n = 350
  • Clinical nutrition (Edinburgh, Scotland) 42(8)
  • • Xudong Yan
    • Xiaoyu Pan
    • Lu Ding
    • Yiheng Dai
    • Jun Chen
    • Yong Yang
    • Yuefeng Li
    • Hu Hao
    • Huixian Qiu
    • Zhenzhi Ye
    • René Liang Shen
    • Yanqi Li
    • Christian Ritz
    • Yueming Peng
    • Ping Zhou
    • Fei Gao
    • Ping-Ping Jiang
    • Hung-Chih Lin
    • Gitte Zachariassen
    • Per Torp Sangild
    • Benqing Wu

  • PubMed: 37437359
  • DOI: 10.1016/j.clnu.2023.06.024

  3 Insights on

  • Reduced Periventricular Leukomalacia

  • High evidence
  • Large Human Trial
  • Infants

  but more cases of periventricular leukomalacia were detected in the infants fed BC (5/155 vs. 0/181, P = 0.06)

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  Volume restricted by recommended protein intake (4-4.5 g/kg/d)