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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Cissus quadrangularis and Increased Intestinal GLP-1 Levels

Doses used in studies

mg/day: 300 (median 300, IQR 300–300) — 1 study

Time to effect

Median: 3.7 months · IQR 3.7 months–3.7 months · Range 3.7 months–3.7 months — Reported in 1 of 1 study

1 of 1 paper

Effects of Dichrostachys glomerata and Cissus quadrangularis Extracts on GLP-1 Secretion and DPP-4 Activity in Overweight and Obese Individuals: A Randomized Controlled Trial.
- 2025-12-25
- RCT · n = 248
- Medicina (Kaunas, Lithuania) 62(1)
- - Janvier Youovop
  - Guy Takuissu
  - Régine Minoue
  - Felix Nwang
  - Maryam Adegboyega
  - Crista Arrey
  - Inelle Makamwe
  - Julius Oben
- PubMed: 41597327
- DOI: 10.3390/medicina62010041
8 Insights on
- Increased Intestinal GLP-1 Levels
- High evidence
- Large Human Trial
- Adults
Participants receiving DGE or CQE displayed notable elevations in circulating GLP-1 (+38.6 pg/mL and +42.2 pg/mL, respectively; p < 0.01)
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
300 mg/day