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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Cissus quadrangularis and Reduced Fasting Blood Glucose Levels

Doses used in studies

mg/day: 300 (median 300, IQR 300–300) — 1 study

Time to effect

Median: 3 months · IQR 11.5 weeks–3.4 months · Range 10 weeks–3.7 months — Reported in 2 of 2 studies

2 of 2 papersPopulation:

Effects of Dichrostachys glomerata and Cissus quadrangularis Extracts on GLP-1 Secretion and DPP-4 Activity in Overweight and Obese Individuals: A Randomized Controlled Trial.
- 2025-12-25
- RCT · n = 248
- Medicina (Kaunas, Lithuania) 62(1)
- - Janvier Youovop
  - Guy Takuissu
  - Régine Minoue
  - Felix Nwang
  - Maryam Adegboyega
  - Crista Arrey
  - Inelle Makamwe
  - Julius Oben
- PubMed: 41597327
- DOI: 10.3390/medicina62010041
8 Insights on
- Reduced Fasting Blood Glucose Levels
- High evidence
- Large Human Trial
- Adults
Significant changes in fasting glucose and serum lipid levels were also observed (p < 0.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
300 mg/day
The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study.
- 2008
- RCT · n = 24
- Lipids in health and disease 7(1)
- - Julius E Oben
  - Judith L Ngondi
  - Claudia N Momo
  - Gabriel A Agbor
  - Caroline S Makamto Sobgui
- PubMed: 18377661
- DOI: 10.1186/1476-511x-7-12
6 Insights on
- Reduced Fasting Blood Glucose Levels
- High evidence
- Clinical
the Cissus quadrangularis-only group showed significant reductions on all variables compared to the placebo group
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
twice daily before meals (exact dose not specified in abstract)