Coffee and Reduced Risk of Multiple Sclerosis

• Coffee consumption and risk of multiple sclerosis: A systematic review and meta-analysis.

  • 2025-06
  • Meta-Analysis · n = 430
  • Autoimmunity reviews 24(7)
  • • Mehrad Amirnia
    • Khazar Raeisnia
    • Hamidreza Ashayeri
    • Zahra Hakimzadeh
    • Ehsan Nasiri
    • Mahnaz Talebi
    • Sarvin Sanaie
    • Amirreza Naseri

  • PubMed: 40286889
  • DOI: 10.1016/j.autrev.2025.103822

  1 Insight on

  • Reduced Risk of Multiple Sclerosis

  • High evidence
  • Clinical

  Meta-analysis revealed a reduction in MS development in coffee consumers both before (OR: 0.66; 95 % CI: 0.49-0.90; p-value: 0.008; I2: 89.65 %; p-value for heterogeneity<0.001) and after adjustment for possible confounders (adjusted OR: 0.42; 95 % CI: 0.20-0.90; p-value: 0.025; I2: 89.65 l; p-value for heterogeneity<0.001).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes