Colostrum and Increased Angiopoietin Level

• Therapeutic interventions targeting enteropathy in severe acute malnutrition modulate systemic and vascular inflammation and epithelial regeneration.

  • 2025-01
  • RCT · n = 122
  • EBioMedicine 111
  • • Jonathan P Sturgeon
    • Kuda Mutasa
    • Mutsa Bwakura-Dangarembizi
    • Beatrice Amadi
    • Deophine Ngosa
    • Anesu Dzikiti
    • Kanta Chandwe
    • Ellen Besa
    • Batsirai Mutasa
    • Simon H Murch
    • Susan Hill
    • Raymond J Playford
    • Kelley VanBuskirk
    • Paul Kelly
    • Andrew J Prendergast

  • PubMed: 39662176
  • DOI: 10.1016/j.ebiom.2024.105478

  8 Insights on

  • Increased Angiopoietin Level

  • High evidence
  • Large Human Trial
  • Children

  N-acetylglucosamine, a precursor for epithelial glycosaminoglycan synthesis, increased biomarkers of epithelial regeneration (EGF, VEGF), and circulating growth factors (angiopoietin, IGFBP-3, and GCSF).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes