Echinacea and Increased Interleukin 8 Levels

Doses used in studies

g/day: 10.2–5.1 (median 7.65, IQR 10.2–5.1) — 1 study

Time to effect

Median: 5 days · IQR 5 days–5 days · Range 5 days–5 days — Reported in 1 of 1 study

1 of 1 paper

Echinacea for treating the common cold: a randomized trial.

2010-12-21
RCT · n = 719
Annals of internal medicine 153(12)
- Bruce Barrett
- Roger Brown
- Dave Rakel
- Marlon Mundt
- Kerry Bone
- Shari Barlow
- Tola Ewers

PubMed: 21173411
DOI: 10.7326/0003-4819-153-12-201012210-00003

4 Insights on

Increased Interleukin 8 Levels

High evidence
Large Human Trial
Rigorous Journal
Clinical

Median change in interleukin-8 levels and neutrophil counts were also not statistically significant (30 ng/L and 1 cell/high-power field [hpf] in the no-pill group, 39 ng/L and 1 cell/hpf in the blinded placebo group, 58 ng/L and 2 cells/hpf in the blinded echinacea group, and 70 ng/L and 1 cell/hpf in the open-label echinacea group).

Effect: Neutral
Effect size: Small
Significant: No
Dose: equivalent of 10.2 g of dried echinacea root during the first 24 hours and 5.1 g during each of the next 4 days