Echinacea and Reduced International Normalized Ratio

• Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects.

  • 2010-04-12
  • RCT · n = 12
  • British journal of clinical pharmacology 69(5)
  • • Mohi Iqbal Mohammed Abdul
    • Xuemin Jiang
    • Kenneth M Williams
    • Richard O Day
    • Basil D Roufogalis
    • Winston S Liauw
    • Hongmei Xu
    • Anita Matthias
    • Reginald P Lehmann
    • Andrew J McLachlan

  • PubMed: 20573086
  • DOI: 10.1111/j.1365-2125.2010.03620.x

  2 Insights on

  • Reduced International Normalized Ratio

  • High evidence
  • Adults

  this did not lead to a clinically significant change in INR (90% CI of AUC of INR; 0.91, 1.31).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  recommended doses for 2 weeks