Fenugreek Seed and Reduced Systolic Blood Pressure

Research synthesisLow evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial small effects on systolic blood pressure, while 1 found neutral between-group results. The predominant effect size is small. The most-studied dose is approximately 15 g/day of fenugreek seed. Median study duration is 88 days (about 12.6 weeks), indicating effects are typically observed at 8–12 weeks. Evidence is drawn from clinical populations including type 2 diabetes and Alzheimer's disease.

Effective dose range: approximately 15 g/day (e.g., 5 g three times daily)
Studied populations: people with type 2 diabetes and Alzheimer's disease

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. One study reported a neutral between-group effect despite a within-group reduction, suggesting potential confounding or smaller effect in certain populations. Doses varied across studies (whole seed vs. extract), limiting direct comparability.

Generated Jul 13, 2026

Doses used in studies

g/day: 15 (median 15, IQR 15–15) — 2 studies
cc/day: 5 (median 5, IQR 5–5) — 1 study

Time to effect

Median: 2.9 months · IQR 10.3 weeks–3.5 months · Range 8 weeks–4 months — Reported in 2 of 3 studies

3 of 3 papersPopulation:

The Effects of Fenugreek Seed Consumption on Blood Pressure: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
- 2023-02-10
- Meta-Analysis · n = 373
- High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension 30(2)
- - Mohammad Reza Amini
  - Nastaran Payandeh
  - Fatemeh Sheikhhossein
  - Sanaz Pourreza
  - Hamid Ghalandari
  - Moein Askarpour
  - Azita Hekmatdoost
- PubMed: 36763260
- DOI: 10.1007/s40292-023-00565-6
2 Insights on
- Reduced Systolic Blood Pressure
- High evidence
Fenugreek seed supplementation significantly reduced SBP (WMD: 3.46 mmHg, 95% CI - 6.33, - 0.59, P=0.018)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
≥ 15 g/day (subgroup), overall unspecified
The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial.
- 2020-03
- RCT · n = 50
- Complementary therapies in medicine 49
- - Amir Hadi
  - Arman Arab
  - Hossein Hajianfar
  - Behrouz Talaei
  - Maryam Miraghajani
  - Siavash Babajafari
  - Wolfgang Marx
  - Rahele Tavakoly
- PubMed: 32147060
- DOI: 10.1016/j.ctim.2020.102315
10 Insights on
- Reduced Systolic Blood Pressure
- High evidence
- Clinical
Within-group analysis showed a significant decrease in systolic blood pressure (SBP) (p = 0.001) in the FS group
Effect
Neutral
Effect size
Small
Significant
No
Dose
5 g, 3 times a day
The effects of fenugreek seed extract supplementation in patients with Alzheimer's disease: A randomized, double-blind, placebo-controlled trial.
- 2022-10-05
- RCT
- Phytotherapy research : PTR 37(1)
- - Elaheh Foroumandi
  - Roghayeh Javan
  - Leili Moayed
  - Hossein Fahimi
  - Fereshteh Kheirabadi
  - Mahboubeh Neamatshahi
  - Fazeleh Shogofteh
  - Azam Zarghi
- PubMed: 36199177
- DOI: 10.1002/ptr.7612
7 Insights on
- Reduced Systolic Blood Pressure
- High evidence
- Clinical
reduction of systolic BP (p < 0.001)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
5 cc

Fenugreek Seed and Reduced Systolic Blood Pressure

The Effects of Fenugreek Seed Consumption on Blood Pressure: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial.

The effects of fenugreek seed extract supplementation in patients with Alzheimer's disease: A randomized, double-blind, placebo-controlled trial.