The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial.
- 2025-07
- RCT · n = 57
- Journal of affective disorders 380
- Murat Açik
- Funda Pınar Çakiroğlu
- Atilla Tekin
- Aslı Egeli
- PubMed: 40118278
- DOI: 10.1016/j.jad.2025.03.097
- High evidence
- Clinical
Krill- and fish-oil supplementation increased plasma HDL-c and uric acid levels, but the group-by-time interaction effect was only observed at the HDL-c level (η2p = 0.238; p_time×group = 0.002).
- Effect
- Beneficial
- Effect size
- Small
- Significant
- Yes
- Dose
- 600 mg EPA + DHA daily