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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Fish Oil and Reduced Hemoglobin A1c

Doses used in studies

mg/day: 600 (median 600, IQR 600–600) — 1 study

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 2 of 2 studies

2 of 2 papers

The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial.
- 2025-07
- RCT · n = 57
- Journal of affective disorders 380
- - Murat Açik
  - Funda Pınar Çakiroğlu
  - Atilla Tekin
  - Aslı Egeli
- PubMed: 40118278
- DOI: 10.1016/j.jad.2025.03.097
10 Insights on
- Reduced Hemoglobin A1c
- High evidence
- Clinical
The mean HbA1c rates and plasma triglyceride levels of krill-oil recipients were lower after the post-intervention. (No significant change reported for fish oil on these outcomes)
Effect
Neutral
Effect size
Small
Significant
No
Dose
600 mg EPA + DHA daily
The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population.
- 2014-12
- RCT
- Lipids in health and disease 13(1)
- - Tammy C Lee
  - Priscilla Ivester
  - Austin G Hester
  - Susan Sergeant
  - Larry Douglas Case
  - Timothy Morgan
  - Ethel O Kouba
  - Floyd H Chilton
- PubMed: 25515553
- DOI: 10.1186/1476-511x-13-196
2 Insights on
- Reduced Hemoglobin A1c
- High evidence
- Clinical
FO reduced serum triglycerides, hemoglobin A1c and increased HDL-cholesterol
Effect
Beneficial
Effect size
Small
Significant
Yes