flaxseed and Reduced Systolic Blood Pressure

Research synthesisLow evidenceModerate effect4 studies · 3 beneficial · 1 neutral · 0 harmful

Across 4 studies, 3 reported beneficial moderate-sized reductions in systolic blood pressure, but the highest-quality meta-analysis (n=1136, evidence score 7) found no significant effect (SMD 0.50; 95% CI: -1.25 to 0.25, p=0.193). The beneficial studies showed moderate reductions (WMD -4.30 to -8.64 mmHg) in clinical populations with metabolic diseases, type 2 diabetes, cardiovascular risk factors, or hypertension. No consistent dose or form was reported across studies.

Studied populations: patients with metabolic diseases, type 2 diabetes, cardiovascular risk factors, or hypertension

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. The highest-quality meta-analysis (large sample, GRADE-assessed) found no significant benefit, conflicting with three lower-quality reviews. Doses and forms were not consistently reported, limiting the ability to identify an effective regimen.

Generated Jul 10, 2026

Doses used in studies

Glycinate · mg/day: 420 (median 420, IQR 420–420) — 1 study

4 of 4 papers

The effect of flaxseed supplementation on anthropometric indices, blood pressure, and lipid profile in diabetic patients: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials.
- 2025-05
- Meta-Analysis · n = 1,136
- Diabetes & metabolic syndrome 19(5)
- - Vali Musazadeh
  - Shokufeh Nezamoleslami
  - Amir Hossein Faghfouri
  - Farzad Shidfar
  - Naheed Aryaeian
- PubMed: 40499336
- DOI: 10.1016/j.dsx.2025.103241
9 Insights on
- Reduced Systolic Blood Pressure
- High evidence
- Clinical
systolic blood pressure (SMD: 0.50; 95% CI: 1.25, 0.25, p = 0.193)
Effect
Neutral
Effect size
Small
Significant
No
Can flaxseed supplementation alleviate blood pressure in patients with metabolic diseases? Evaluating the strength of evidence using a meta-analysis and GRADE approach.
- 2025-06-12
- Review · n = 209
- Journal of diabetes and metabolic disorders 24(2)
- - Vali Musazadeh
  - Niloofar Hamidi
  - Mahsa Mahmoudinezhad
  - Ali Jafari
  - Farzad Shidfar
- PubMed: 40520241
- DOI: 10.1007/s40200-025-01656-y
2 Insights on
- Reduced Systolic Blood Pressure
- High evidence
- Clinical
Meta-analysis of 18 trials ... revealed significant reductions in both systolic (WMD: -4.30 mmHg; 95% CI: -6.64 to -1.96, p < 0.001)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Efficacy of flaxseed in reducing blood pressure among patients with cardiovascular risk factors: A systematic review and meta-analysis of parallel randomized controlled trials.
- 2025-03-18
- Review
- Journal of cardiovascular and thoracic research 17(1)
- - Refli Hasan
  - Raed Obaid Saleh
  - Rana H Raheema
  - Hanen Mahmod Hulail
  - Irfan Ahmad
  - Deepak Nathiya
  - Parjinder Kaur
- PubMed: 40365516
- DOI: 10.34172/jcvtr.025.33280
2 Insights on
- Reduced Systolic Blood Pressure
- Low evidence
- Clinical
Pooled analysis suggested that flaxseed supplementation can reduce systolic BP (SBP) (WMD: -4.75 mmHg, 95% CI: -7.05 to -2.44, P≤0.001; I²=93.6%)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
not specified in abstract
Flaxseed Lowers Blood Pressure in Hypertensive Subjects: A Meta-Analysis of Randomized Controlled Trials.
- 2024-10-29
- Review
- Clinical nutrition research 13(4)
- - Ezatollah Fazeli Moghadam
  - Leili Khaghani
  - Parivash Shekarchizadeh-Esfahani
- PubMed: 39526211
- DOI: 10.7762/cnr.2024.13.4.295
2 Insights on
- Reduced Systolic Blood Pressure
- Low evidence
- Clinical
significant decrease in systolic BP (WMD, -8.64 mmHg; 95% CI, -15.41 to -1.87; p ≤ 0.001)
Effect
Beneficial
Effect size
Moderate
Significant
Yes

flaxseed and Reduced Systolic Blood Pressure

The effect of flaxseed supplementation on anthropometric indices, blood pressure, and lipid profile in diabetic patients: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials.

Can flaxseed supplementation alleviate blood pressure in patients with metabolic diseases? Evaluating the strength of evidence using a meta-analysis and GRADE approach.

Efficacy of flaxseed in reducing blood pressure among patients with cardiovascular risk factors: A systematic review and meta-analysis of parallel randomized controlled trials.

Flaxseed Lowers Blood Pressure in Hypertensive Subjects: A Meta-Analysis of Randomized Controlled Trials.