Lactobacillus plantarum and Increased High-Density Lipoprotein Cholesterol

• Effect of Probiotics Containing Lactobacillus plantarum on Blood Lipids: Systematic Review, Meta-Analysis, and Network Pharmacological Analysis.

  • 2025-09-23
  • Review · n = 2,104
  • Foods (Basel, Switzerland) 14(19)
  • • Jinshi Zuo
    • Dan Huang
    • Jie Liu
    • Zidan Wang
    • Yuerong Ren
    • Yang Su
    • Yuxia Ma

  • PubMed: 41097469
  • DOI: 10.3390/foods14193300

  6 Insights on

  • Increased High-Density Lipoprotein Cholesterol

  • High evidence

  L. plantarum supplementation significantly reduced TC (SMD: -0.233; 95% CI: -0.458, -0.008; p = 0.042), TG (SMD: -0.227; 95% CI: -0.432, -0.021; p = 0.030), and LDL-C (SMD: -0.251; 95% CI: -0.477, -0.025; p = 0.029), but not HDL-C.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

• Effects of Lactobacillus plantarum supplementation on glucose and lipid metabolism in type 2 diabetes mellitus and prediabetes: A systematic review and meta-analysis of randomized controlled trials.

  • 2024-06
  • Meta-Analysis · n = 5
  • Clinical nutrition ESPEN 61
  • • Hao Zhong
    • Lingmiao Wang
    • Fuhuai Jia
    • Yongqiu Yan
    • Feifei Xiong
    • Yunhong Li
    • Khemayanto Hidayat
    • Rongfa Guan

  • PubMed: 38777458
  • DOI: 10.1016/j.clnesp.2024.04.009

  10 Insights on

  • Increased High-Density Lipoprotein Cholesterol

  • High evidence
  • Clinical

  high-density lipoprotein cholesterol (MD: 1.34; 95%CI: -0.78, 3.46 mg/dL; n = 3)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  No