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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Manuka Honey and Reduced Postoperative Pain

Doses used in studies

ml/day: 10–30 (median 20, IQR 10–30) — 1 study

Time to effect

Median: 7 days · IQR 7 days–7 days · Range 7 days–7 days — Reported in 1 of 1 study

Safety in these studies

vomitingIncreased risk
Children allocated to the honey and placebo groups showed some improved oral tolerance around day 6 but had increased vomiting during earlier days.
from: Impact of honey on post-tonsillectomy pain in children (BEE PAIN FREE Trial): a multicentr

1 of 1 paper

Impact of honey on post-tonsillectomy pain in children (BEE PAIN FREE Trial): a multicentre, double-blind, randomised controlled trial.
- 2025-05-05
- RCT · n = 400
- Anaesthesia 80(8)
- - David Sommerfield
  - Aine Sommerfield
  - Daisy Evans
  - Neil Hauser
  - Shyan Vijayasekaran
  - Paul Bumbak
  - Hayley Herbert
  - Cornelia Locher
  - Lee Yong Lim
  - R Nazim Khan
  - Britta S von Ungern-Sternberg
- PubMed: 40321015
- DOI: 10.1111/anae.16619
7 Insights on
- Reduced Postoperative Pain
- High evidence
- Large Human Trial
- Clinical
Treatment with honey at this frequency did not impact postoperative pain scores significantly, with all groups showing similar trajectories.
Effect
Neutral
Effect size
Small
Significant
No
Dose
5 ml, six times a day, for at least 7 days (mean 2-3 doses per day)