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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Olive Oil and Increased High-Density Lipoprotein Cholesterol

Doses used in studies

g/day: 8–20 (median 14, IQR 8–20) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
The volumes used (8-20 g/day) reflect typical daily EVOO intake and were well tolerated by participants.
from: Effects of High-Phenolic Extra Virgin Olive Oil (EVOO) on the Lipid Profile of Patients wi

2 of 2 papersPopulation:

Effects of High-Phenolic Extra Virgin Olive Oil (EVOO) on the Lipid Profile of Patients with Hyperlipidemia: A Randomized Clinical Trial.
- 2025-08-02
- RCT
- Nutrients 17(15)
- - Christos Kourek
  - Emmanouil Makaris
  - Prokopios Magiatis
  - Virginia Zouganeli
  - Vassiliki Benetou
  - Alexandros Briasoulis
  - Andrew Xanthopoulos
  - Ioannis Paraskevaidis
  - Eleni Melliou
  - Georgios Koudounis
  - Philippos Orfanos
- PubMed: 40806126
- DOI: 10.3390/nu17152543
2 Insights on
- Increased High-Density Lipoprotein Cholesterol
- High evidence
- Rigorous Journal
- Clinical
EVOO intake was associated with a significant increase in HDL (p < 0.001) ... among hyperlipidemic patients in comparison to healthy individuals.
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
8-20 g/day
[Oil and life: The impact of olive oil on human health. A review of the evidence supporting the recommendation for extra virgin olive oil consumption].
- 2025-11
- Review
- Semergen 51(8)
- - J M Rubio López
- PubMed: 40929788
- DOI: 10.1016/j.semerg.2025.102582
11 Insights on
- Increased High-Density Lipoprotein Cholesterol
- Low evidence
Rich in monounsaturated fatty acids, such as oleic acid, and bioactive compounds like polyphenols and tocopherols, EVOO helps reduce LDL cholesterol, increase HDL cholesterol, and protect against oxidative stress.
Effect
Beneficial
Effect size
Small
Significant
Yes