Efficacy of Topical Betamethasone Valerate and Olive Oil in Preventing Acute Radiation Dermatitis in Breast Cancer: A Randomized Double-Blind Placebo-Controlled Study.
- 2026-01
- RCT · n = 132
- Clinical breast cancer 26(1)
- Israa K Mohamed
- Maggie M Abbassi
- Mohamed R Kelany
- Samar F Farid
- PubMed: 40973558
- DOI: 10.1016/j.clbc.2025.08.008
- High evidence
- Large Human Trial
- Clinical
Betamethasone and olive oil significantly differed from the unmedicated cream base at weeks 1 to 4 (P < 0.05). At week 5, only significance was observed between olive oil and unmedicated cream base (P = 0.013), and the mean RTOG score was significantly lower in olive oil and betamethasone groups than in the unmedicated cream base group (P < 0.05 at weeks 1-5) but, there was no significant difference between olive oil and betamethasone (P > 0.999).
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes