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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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plantain leaf and Reduced Oral Mucositis Severity

Research synthesisLow evidenceModerate effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial moderate-sized effects of plantain leaf on reducing oral mucositis severity in cancer patients, while 1 small neutral trial found no significant benefit. The predominant effect size is moderate in systematic reviews, but the only RCT showed a small, non-significant effect. No consistent dose or form data were extracted. The median study duration was 14 days (from 1 study).

  • Studied populations: cancer patients (solid tumour, head and neck cancer) with chemotherapy- or radiotherapy-induced oral mucositis

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The two beneficial studies are systematic reviews that include plantain leaf among other interventions, while the only direct RCT found a neutral small effect that did not reach statistical significance. Publication bias may inflate the apparent benefit, as null results are less likely to be published.

Generated Jul 11, 2026
Time to effect
Median: 2 weeks · IQR 2 weeks–2 weeks · Range 2 weeks–2 weeks — Reported in 1 of 3 studies
3 of 3 papers
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