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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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plantain leaf and Reduced Oral Mucositis Severity

Research synthesisLow evidenceModerate effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial moderate-sized effects of plantain leaf on reducing oral mucositis severity in cancer patients, while 1 small neutral trial found no significant benefit. The evidence base is small and preliminary, with effects observed primarily in clinical populations of patients with cancer undergoing radiation or chemotherapy.

  • Studied populations: cancer patients (including head and neck cancer) with oral mucositis from radiation or chemotherapy

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The one RCT (n=50) showed a neutral, non-significant effect, conflicting with the two systematic reviews that reported benefits; this may reflect differences in study design or outcome measurement. Dosing and form were not consistently reported across studies.

Generated Jun 11, 2026
Time to effect
Median: 2 weeks · IQR 2 weeks–2 weeks · Range 2 weeks–2 weeks — Reported in 1 of 3 studies
3 of 3 papers
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