Propolis and Reduced 8-OHdG Level

• Comparative evaluation of propolis, fluoride and probiotic mouthwashes on streptococcus mutans and oxidative stress in fixed orthodontic patients: A triple-blind, randomized controlled trial with 9-month follow-up.

  • 2025-12
  • RCT · n = 120
  • International orthodontics 23(4)
  • • Praveen Chandrashekaraiah
    • Reshma Benzigar
    • Ramya Shivananjan
    • Selva Arockiam
    • Nithya Nandhini
    • Sangeetha Ulaganathan

  • PubMed: 40378578
  • DOI: 10.1016/j.ortho.2025.101017

  2 Insights on

  • Reduced 8-OHdG Level

  • High evidence
  • Large Human Trial
  • Clinical

  Salivary 8-OHdG (ng/mL) declined significantly (P<0.001): 3.8±0.8 to 0.32±0.14 (propolis)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes