Propolis and Reduced Streptococcus Mutans Levels

• Comparative evaluation of propolis, fluoride and probiotic mouthwashes on streptococcus mutans and oxidative stress in fixed orthodontic patients: A triple-blind, randomized controlled trial with 9-month follow-up.

  • 2025-12
  • RCT · n = 120
  • International orthodontics 23(4)
  • • Praveen Chandrashekaraiah
    • Reshma Benzigar
    • Ramya Shivananjan
    • Selva Arockiam
    • Nithya Nandhini
    • Sangeetha Ulaganathan

  • PubMed: 40378578
  • DOI: 10.1016/j.ortho.2025.101017

  2 Insights on

  • Reduced Streptococcus Mutans Levels

  • High evidence
  • Large Human Trial
  • Clinical

  S. mutans levels (log10 CFU/mL) significantly decreased (P<0.001) at 9 months: from 4.35±0.45 to 0.89±0.06 (propolis)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Natural Compounds in Oral Microbiota Modulation and Caries Prevention: A Systematic Review.

  • 2025-11-05
  • Review · n = 77
  • Dentistry journal 13(11)
  • • María Del Pilar Angarita-Díaz
    • Lilia J Bernal-Cepeda
    • Jéssica María Sarmiento-Ordoñez
    • Yohan Yañez-Navas
    • Karen Garcia-Plazas
    • Hermann Gutierrez-Reyes
    • Laura Correa-Guataquira

  • PubMed: 41294499
  • DOI: 10.3390/dj13110518

  2 Insights on

  • Reduced Streptococcus Mutans Levels

  • Moderate evidence
  • Clinical

  The most frequently studied components included probiotics, plant extracts, sugar substitutes, propolis, arginine, dairy products, among others. Significant effects were most reported on biological risk factors (72.8%).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes