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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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saccharomyces boulardii and Reduced Stool Frequency

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial moderate-sized effects of Saccharomyces boulardii on reducing stool frequency in children with acute diarrhea. The most common dose was 250 mg twice daily, and the evidence consistently supports a reduction in stool frequency within 3–6 days. Effects were predominantly moderate across studies.

  • Effective dose range: 250 mg twice daily
  • Studied populations: Children aged 2 months to 12 years with acute diarrhea or acute infectious gastroenteritis

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Study durations were not consistently reported, and one study did not specify a dose.

Generated Jun 11, 2026
Doses used in studies
  • mg/day: 500 (median 500, IQR 500–500) — 1 study
Safety in these studies
3 of 3 papers
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