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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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saccharomyces boulardii and Reduced Stool Frequency

Research synthesisModerate evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Saccharomyces boulardii on reducing stool frequency in children with acute diarrhea, with effect sizes ranging from small to large. The most-studied population is children aged 2 months to 12 years. Doses were not consistently reported across studies, but one trial used 250 mg twice daily.

  • Effective dose range: 250 mg bid
  • Studied populations: Children with acute diarrhea (including acute infectious gastroenteritis, ages 2 months to 12 years)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed).

Generated May 12, 2026
Doses used in studies
  • mg/day: 500 (median 500, IQR 500–500) — 1 study
Safety in these studies
3 of 3 papers
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