Crocus sativus (saffron) adjunct to risperidone for negative symptoms of schizophrenia: a randomized, double-blind, placebo-controlled trial.
- 2024-12-12
- RCT
- International clinical psychopharmacology 40(6)
- Siamand Mazhar
- Ahmad Shamabadi
- Kimia Kazemzadeh
- Mohammad Aidin Farahvash
- Atiye Heidari Dalfard
- Bita Fallahpour
- Mohammad-Reza Khodaei Ardakani
- Shahin Akhondzadeh
- PubMed: 39661337
- DOI: 10.1097/yic.0000000000000575
- High evidence
- Clinical
There were significant time-treatment interaction effects on... general psychopathology ( = 0.193)... their reductions were significantly greater in the saffron group until weeks 4 (Cohen's d s = 0.898) and 8 (Cohen's d s = 1.047)
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes
- Dose
- 15 mg q12hr (30 mg/day)