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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Saffron and Reduced Hemoglobin A1c

Research synthesisLow evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported small beneficial effects of saffron supplementation on reducing hemoglobin A1c (HbA1c), while 1 found no significant effect. The two positive meta-analyses showed small reductions of approximately -0.22% to -0.25% in clinical populations with metabolic syndrome, type 2 diabetes, or related conditions. Doses ranged from 5 mg/day to 1 g/day, but no consistent dose range emerged.

  • Studied populations: patients with metabolic syndrome, type 2 diabetes, and related conditions

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. One of three meta-analyses found no significant effect, suggesting inconsistency. Doses and durations varied widely across studies, limiting comparability.

Generated Jul 10, 2026
Doses used in studies
  • mg/day: 5–1,000 (median 502.5, IQR 5–1,000) — 1 study
3 of 3 papers
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