Across 3 studies (all meta-analyses or systematic reviews), sesame supplementation consistently showed beneficial large effects on reducing fasting blood glucose levels. All 3 studies reported statistically significant reductions, with effect sizes ranging from moderate to large. Effects were observed in populations with diabetes or elevated cardiometabolic risk, typically over 6 weeks.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Dose information was not extracted from the included studies, limiting practical guidance.
Improvements were also observed in glycemic control, with reductions in fasting blood glucose and HbA1c levels.
Sesame supplementation significantly reduced fasting glucose (WMD = -28.48; 95 % CI: 37.66, -19.30; P < 0.001)
The meta-analyses revealed that sesame consumption significantly decreases serum fasting blood sugar (FBS): (WMD: -28.23 mg/dl; 95% CI (-39.16, -17.13), I² = 97.6%; 95% CI (96, 98))