Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2025-01
- Meta-Analysis · n = 3,285
- Advances in nutrition (Bethesda, Md.) 16(1)
- Gabrielle Viscardi
- Songhee Back
- Amna Ahmed
- Shuting Yang
- Sonia Blanco Mejia
- Andreea Zurbau
- Tauseef A Khan
- Amanda Selk
- Mark Messina
- Cyril Wc Kendall
- David Ja Jenkins
- John L Sievenpiper
- Laura Chiavaroli
- PubMed: 39433088
- DOI: 10.1016/j.advnut.2024.100327
- High evidence
- Clinical
Soy isoflavones had no statistically significant effect on any measure of estrogenicity; ET [mean difference, -0.22 mm (95% confidence interval, -0.45, 0.01 mm), P_MD = 0.059]
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 75 mg/d (median reported dose)