Soy and Reduced Follicle Stimulating Hormone

• Assessing the combined effects of Black Cohosh, Soy Isoflavones, and SDG Lignans on menopausal symptoms: a randomized, double-blind, placebo-controlled clinical trial.

  • 2025-03-25
  • RCT · n = 90
  • European journal of nutrition 64(3)
  • • Evgeny Pokushalov
    • A Ponomarenko
    • C Garcia
    • L Kasimova
    • I Pak
    • E Shrainer
    • A Romanova
    • D Kudlay
    • M Johnson
    • R Miller

  • PubMed: 40131516
  • DOI: 10.1007/s00394-025-03588-y

  6 Insights on

  • Reduced Follicle Stimulating Hormone

  • High evidence
  • Rigorous Journal
  • Adults

  Hormonal changes were modest yet statistically significant for FSH (- 6.7% difference, p < 0.01)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

  • 2025-01
  • Meta-Analysis · n = 3,285
  • Advances in nutrition (Bethesda, Md.) 16(1)
  • • Gabrielle Viscardi
    • Songhee Back
    • Amna Ahmed
    • Shuting Yang
    • Sonia Blanco Mejia
    • Andreea Zurbau
    • Tauseef A Khan
    • Amanda Selk
    • Mark Messina
    • Cyril Wc Kendall
    • David Ja Jenkins
    • John L Sievenpiper
    • Laura Chiavaroli

  • PubMed: 39433088
  • DOI: 10.1016/j.advnut.2024.100327

  4 Insights on

  • Reduced Follicle Stimulating Hormone

  • High evidence
  • Clinical

  Soy isoflavones had no statistically significant effect on any measure of estrogenicity; FSH [-0.02 IU/L (-2.39, 2.35 IU/L), P_MD = 0.987]

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  75 mg/d (median reported dose)