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Evidence-Based Supplement Research

Evidence-Based Supplement Research

tart cherry and Reduced Uric Acid Levels

Doses used in studies

ml/day: 15–60 (median 37.5, IQR 15–60) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 2 studies

Safety in these studies

hyperglycemiaReported
There were 24 reported adverse events, with only one (hyperglycaemia) considered possibly to be related to cherry concentrate.
from: Lack of effect of tart cherry concentrate dose on serum urate in people with gout.

2 of 2 papersPopulation:

Tart cherry intake and serum uric acid: Meta-analysis of randomized controlled trials and evidence from network pharmacology.
- 2026-06-01
- Meta-Analysis · n = 392
- Asia Pacific journal of clinical nutrition 35(3)
- - Zhenzhen Zhang
  - Zhiyuan Feng
  - Wei Yan
  - Tianyu Wu
  - Jiayue Xia
  - Junhui Yu
  - Jingyi Yang
  - Yuanyuan Wang
  - Guiju Sun
- PubMed: 42242852
- DOI: 10.6133/apjcn.202606_35(3).0008
1 Insight on
- Reduced Uric Acid Levels
- High evidence
Tart cherry intake was associated with a modest reduction in serum uric acid concentration compared with control (standardized mean difference -0.22; 95% confidence interval -0.43 to -0.01)
Effect
Beneficial
Effect size
Small
Significant
Yes
Lack of effect of tart cherry concentrate dose on serum urate in people with gout.
- 2019-12-31
- RCT
- Rheumatology (Oxford, England) 59(9)
- - Lisa K Stamp
  - Peter Chapman
  - Christopher Frampton
  - Stephen B Duffull
  - Jill Drake
  - Yuqing Zhang
  - Tuhina Neogi
- PubMed: 31891407
- DOI: 10.1093/rheumatology/kez606
3 Insights on
- Reduced Uric Acid Levels
- High evidence
- Clinical
no significant effect on ... frequency of gout flares over the 28-day study period (P = 0.76)
Effect
Neutral
Effect size
Small
Significant
No
Dose
7.5 ml, 15 ml, 22.5 ml, or 30 ml twice daily