Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.
- 2025-10
- Meta-Analysis · n = 415
- Clinical nutrition ESPEN 69
- Ping Luo
- Jingfeng Chen
- Kang Liu
- Jia Zhang
- PubMed: 40789388
- DOI: 10.1016/j.clnesp.2025.07.1130
- High evidence
- Elderly
Subgroup analysis showed that the combined supplementation of l-citrulline and l-arginine significantly decreased SBP (-10.44 mmHg [95 % CI: -13.57 to -7.31], P < 0.00001)
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes