Acetyl-Carnitine and Reduced Depression Symptoms

• Current Evidence of Acetyl-L-Carnitine Use in Mood Disorders-: A Systematic Review and Meta-Analysis.

  • 2026-06-03
  • Review · n = 809
  • Neuropsychiatric disease and treatment 22
  • • Rakesh Kumar
    • Zahra Hashempour
    • Sara Shahriarirad
    • Reza Shahriarirad
    • Leslie C Hassett
    • Balwinder Singh
    • Paul E Croarkin
    • Marin Veldic
    • Mark A Frye
    • Sandeep R Pagali

  • PubMed: 42261369
  • DOI: 10.2147/ndt.s586506

  1 Insight on

  • Reduced Depression Symptoms

  • High evidence
  • Clinical

  meta-analysis (n=10) studies (14 randomized controlled trials [RCTs] and 1 open label) involving 809 participants ... revealed that ALC significantly reduces depressive symptoms compared to placebo, with comparable efficacy to standard antidepressants and fewer adverse effects.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes