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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Acetyl-Carnitine and Reduced Fatigue

Safety in these studies

non-serious adverse eventsIncreased riskRR 2.51, 95% CI 0.68 to 9.22
It is unclear whether acetyl-L-carnitine versus placebo increases the risk of non-serious adverse events (8/126 (6.34%) vs 3/120 (2.50%); RR 2.51, 95% CI 0.68 to 9.22; 2 trials; very low-quality evidence).
from: Acetyl-L-carnitine for patients with hepatic encephalopathy.
Overall tolerabilityReported
Overall, adverse events data were poorly reported and harms may have been underestimated.
from: Acetyl-L-carnitine for patients with hepatic encephalopathy.

2 of 2 papers

Acetyl-L-carnitine for patients with hepatic encephalopathy.
- 2019-01-05
- Meta-Analysis · n = 398
- The Cochrane database of systematic reviews 2019(1)
- - Arturo J Martí-Carvajal
  - Christian Gluud
  - Ingrid Arevalo-Rodriguez
  - Cristina Elena Martí-Amarista
- PubMed: 30610762
- DOI: 10.1002/14651858.cd011451.pub2
4 Insights on
- Reduced Fatigue
- High evidence
- Clinical
The effects are uncertain in people with ... mild-grade hepatic encephalopathy (... physical fatigue: 0.20 points, 95% CI -0.72 to 1.12)
Effect
Neutral
Effect size
Small
Significant
No
Dietary supplements and fatigue in patients with breast cancer: a systematic review.
- 2018-06-18
- Systematic Review · n = 932
- Breast cancer research and treatment 171(3)
- - Paula Tâmara Vieira Teixeira Pereira
  - Andréa Dias Reis
  - Andréa Dias Reis
  - Renata Rodrigues Diniz
  - Franciléia Andrade Lima
  - Richard Diego Leite
  - Mayara Cristina Pinto da Silva
  - Rosane Nassar Meireles Guerra
  - Érica Brandão de Moraes Vieira
  - João Batista Santos Garcia
- PubMed: 29915949
- DOI: 10.1007/s10549-018-4857-0
1 Insight on
- Reduced Fatigue
- High evidence
- Clinical
The most commonly used supplements that improve fatigue were guarana, acetyl-L-carnitine, and co-enzyme Q10.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
not stated