Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Acetyl-Carnitine and Reduced Waist Circumference

Doses used in studies

mg/day: 3,000 (median 3,000, IQR 3,000–3,000) — 1 study

Time to effect

Median: 4.4 months · IQR 3.6 months–5.3 months · Range 2.8 months–6.1 months — Reported in 2 of 2 studies

2 of 2 papers

Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial.
- 2021-05-28
- RCT · n = 147
- Advances in therapy 38(7)
- - Saman Tauqir
  - Momina Israr
  - Bushra Rauf
  - Muhammad Omar Malik
  - Syed Hamid Habib
  - Fawad Ali Shah
  - Muhammad Usman
  - Muhammad Asif Raza
  - Inayat Shah
  - Haroon Badshah
  - Ehtesham Ehtesham
  - Mohsin Shah
- PubMed: 34047916
- DOI: 10.1007/s12325-021-01789-5
9 Insights on
- Reduced Waist Circumference
- High evidence
- Large Human Trial
- Clinical
Interestingly, there was a significant improvement in body circumference (p < 0.001) in the combo group.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
1500 mg twice daily
Efficacy Of Combined Nutritional And Pharmacological Interventions In PCOS: A Six Month Randomized Controlled Trial.
- 2025-09-30
- RCT
- Naunyn-Schmiedeberg's archives of pharmacology 399(3)
- - Musarrat Zahra
  - Mohsin Shah
  - Fiza Iqbal
  - Tariq Zubair
  - Rozina Habib
  - Fatima Zulfiqar
- PubMed: 41026176
- DOI: 10.1007/s00210-025-04626-6
3 Insights on
- Reduced Waist Circumference
- High evidence
- Clinical
Repeated-measures ANCOVA showed significant group × time interactions for BMI (p < .001, η2 = .220), waist circumference (p < .001, η2 = .314), and hip circumference (p < .001, η2 = .428), favoring the combination group.
Effect
Beneficial
Effect size
Large
Significant
Yes