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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Arginine and Reduced Blood Pressure

Doses used in studies

g/day: 3.2–9.6 (median 6.4, IQR 3.2–9.6) — 1 study

Time to effect

Median: 4 days · IQR 4 days–4 days · Range 4 days–4 days — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
L-Arg administration is safe
from: L-Arginine supplementation in pregnancy: a systematic review of maternal and fetal outcome

2 of 2 papersPopulation:

Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study.
- 2026-01-01
- RCT
- International journal of sport nutrition and exercise metabolism 36(1)
- - Cezimar Correia Borges
  - Weder Alves da Silva
  - Alberto Souza de Sá Filho
  - Vicente Aprigliano
  - Pedro Augusto Inacio
  - Marina Silveira
  - Gerson Ferrari
- PubMed: 41248623
- DOI: 10.1123/ijsnem.2025-0125
10 Insights on
- Reduced Blood Pressure
- High evidence
- Athletes
no differences were found for blood pressure
Effect
Neutral
Effect size
Small
Significant
No
Dose
3.2-9.6 g/day
L-Arginine supplementation in pregnancy: a systematic review of maternal and fetal outcomes.
- 2023-05-31
- Systematic Review
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 36(1)
- - Daniela Menichini
  - Lia Feliciello
  - Isabella Neri
  - Fabio Facchinetti
- PubMed: 37258415
- DOI: 10.1080/14767058.2023.2217465
7 Insights on
- Reduced Blood Pressure
- High evidence
decreased blood pressure, and reduced the need for antihypertensive drugs in women with Hypertensive Disorders of Pregnancy
Effect
Beneficial
Effect size
Moderate
Significant
Yes