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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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L-Arginine and Reduced Diastolic Blood Pressure

Research synthesisLow evidenceModerate effect4 studies · 2 beneficial · 2 neutral · 0 harmful

Across 4 studies, 2 reported beneficial effects of L-arginine (alone or combined with L-citrulline) on diastolic blood pressure, while 2 found neutral results. The predominant effect size among beneficial studies was moderate, though the evidence base is small. Most studies did not consistently report dose or duration, but the strongest evidence comes from a 2025 meta-analysis in middle-aged and elderly individuals showing a moderate reduction of -4.86 mmHg with combined L-citrulline and L-arginine supplementation.

  • Studied populations: middle-aged and elderly individuals (from the 2025 meta-analysis), pregnant women (from the 2024 systematic review)

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance (2 of 4 were non-significant) — effect may be smaller than the predominant direction suggests. Benefits were observed primarily with combined L-citrulline and L-arginine supplementation, not L-arginine alone.

Generated Jul 13, 2026
Doses used in studies
  • g/day: 3 (median 3, IQR 3–3) — 1 study
4 of 4 papers
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