The effect of L-carnitine supplementation on insulin resistance, sex hormone-binding globulin and lipid profile in overweight/obese women with polycystic ovary syndrome: a randomized clinical trial.
- 2021-11-02
- RCT
- European journal of nutrition 61(3)
- Abbas Ali Sangouni
- Fatemeh Pakravanfar
- Akram Ghadiri-Anari
- Azadeh Nadjarzadeh
- Hossein Fallahzadeh
- Mahdieh Hosseinzadeh
- PubMed: 34727201
- DOI: 10.1007/s00394-021-02659-0
- High evidence
- Rigorous Journal
- Clinical
L-Carnitine supplementation compared to the placebo showed a significant improvement in insulin [- 0.7 (- 7.3 to 4.0) vs. 0.7 (- 3.0 to 5.2); P = 0.001], homeostatic model assessment for insulin resistance [- 0.4 (- 1.7 to 1.1) vs. 0.0 (- 0.7 to 1.3); P = 0.002], quantitative insulin sensitivity check index (+ 0.01 ± 0.02 vs. - 0.01 ± 0.01; P = 0.02)
- Effect
- Beneficial
- Effect size
- Small
- Significant
- Yes
- Dose
- 1000 mg/day