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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Carnitine and Improved Sperm Morphology

Doses used in studies

g/day: 2–15 (median 8.5, IQR 5.25–11.75) — 2 studies

Time to effect

Median: 3 months · IQR 3 months–3 months · Range 3 months–3 months — Reported in 2 of 2 studies

2 of 2 papers

Comparison of L-Carnitine vs. Coq10 and Vitamin E for idiopathic male infertility: a randomized controlled trial.
- 2022-07-01
- RCT · n = 143
- European review for medical and pharmacological sciences 26(13)
- - L Ma
  - Y Sun
- PubMed: 35856361
- DOI: 10.26355/eurrev_202207_29194
5 Insights on
- Improved Sperm Morphology
- High evidence
- Large Human Trial
- Clinical
only progressive sperm motility and morphology improved in the control group
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
100 mg tablet orally, thrice daily
Multi-pharmacological treatment for young subfertile males with chronic prostatitis/chronic pelvic pain syndrome.
- 2024
- RCT · n = 50
- Investigative and clinical urology 65(6)
- - Dong Hyeon Lee
  - Young Dong Yu
- PubMed: 39505516
- DOI: 10.4111/icu.20240191
2 Insights on
- Improved Sperm Morphology
- High evidence
- Clinical
A normal morphology improvement was observed in L-carnitine receiving groups.
Effect
Beneficial
Effect size
Small
Dose
320 mg daily