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Multi-pharmacological treatment for young subfertile males with chronic prostatitis/chronic pelvic pain syndrome.

  • 2024
  • Investigative and clinical urology 65(6)
    • Dong Hyeon Lee
    • Young Dong Yu

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 50
Population
350 CP/CPPS patients (age range, 28-40 years)
Methods
Single-center-based, randomized controlled study; 50 patients randomly allocated to each of 7 therapeutic groups with 1:1 ratio; groups received tadalafil (5 mg daily), L-carnitine (2 g daily), Serenoa repens extract (320 mg daily), or combinations
Duration
3 months

Purpose

This study evaluated the effectiveness of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) treatments using multiple pharmaceutical agents that could simultaneously preserve or enhance fertility capability.

Materials and methods

This was a single-center-based, randomized controlled study, whereas the final analysis evaluated a total 350 CP/CPPS patients (age range, 28-40 years) and 50 patients were randomly allocated to each therapeutic group, with a 1:1 ratio. The therapeutic groups consist of tadalafil (group 1, 5 mg daily), L-carnitine (group 2, 2 g daily), Serenoa repens extract (group 3, 320 mg daily), group 4 (tadalafil+L-carnitine), group 5 (tadalafil+S. repens), group 6 (L-carnitine+S. repens), and group 7 (tadalafil+L-carnitine+S. repens). The treatment outcomes at 3 months post-therapy were analyzed.

Results

At 3 months post-therapy, the mean total sperm motility was significantly improved in all groups. A normal morphology improvement was observed in L-carnitine receiving groups. The mean total score on the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and the mean International Prostate Symptom Score (IPSS) showed the greatest reduction in intensity in group 7. Logistic regression analyses showed that group 5 and group 7 were significantly associated with improvements in total IPSS and total NIH-CPSI scores at 3 months post-therapy. Group 7 was a significant predictor for improving total sperm motility, leukocytospermia and normal form of sperm.

Conclusions

Tadalafil, carnitine, and S. repens combination therapy could be considered a feasible treatment option for CP/CPPS males with subfertility.

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