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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Carnitine and Increased Total Serum Antioxidant Capacity

Doses used in studies

g/day: 3 (median 3, IQR 3–3) — 1 study
mg/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Time to effect

Median: 4.5 weeks · IQR 2.8 weeks–6.3 weeks · Range 7 days–8 weeks — Reported in 2 of 2 studies

2 of 2 papers

The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial.
- 2024-03-06
- RCT · n = 60
- Nutrition journal 23(1)
- - Mahdi Keshani
  - Babak Alikiaii
  - Zahra Babaei
  - Gholamreza Askari
  - Zahra Heidari
  - Manoj Sharma
  - Mohammad Bagherniya
- PubMed: 38444016
- DOI: 10.1186/s12937-024-00934-4
9 Insights on
- Increased Total Serum Antioxidant Capacity
- High evidence
- Clinical
TAC (p < 0.001) significantly improved in the LC group after 7 days.
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
3 g/day
L-Carnitine and synbiotic co-supplementation: beneficial effects on metabolic-endotoxemia, meta-inflammation, and oxidative-stress biomarkers in obese patients: a double blind, randomized, controlled clinical trial.
- 2023
- RCT
- Food & function 14(4)
- - Farnoush Fallah
  - Reza Mahdavi
- PubMed: 36752775
- DOI: 10.1039/d2fo03348h
7 Insights on
- Increased Total Serum Antioxidant Capacity
- High evidence
- Rigorous Journal
- Clinical
No significant changes were observed for the above-mentioned parameters in the L-carnitine + placebo group, except for a significant reduction in IL-10 and TNF-α
Effect
Neutral
Effect size
Small
Significant
No
Dose
2 × 500 mg/day