Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Carnitine and Reduced Creatine Kinase Level

Doses used in studies

g/day: 2 (median 2, IQR 2–2) — 1 study
mg/kg/day: 50 (median 50, IQR 50–50) — 1 study

Time to effect

Median: 6.1 weeks · IQR 5.2 weeks–7.1 weeks · Range 4.3 weeks–8 weeks — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
The abstract does not report any adverse events, side effects, or safety findings. It only reports efficacy/ biomarker outcomes (IGF-1, CK, myostatin, myogenin levels). No tolerability statement is made.
from: l-carnitine downregulate the muscle wasting effect of glucocorticoids in pemphigus patient

2 of 2 papers

L-carnitine decreases myocardial injury in children undergoing open-heart surgery: A randomized controlled trial.
- 2024-04-03
- RCT · n = 60
- European journal of pediatrics 183(6)
- - Wael El Feky
  - Dalia El-Afify
  - Dina Abdelhai
  - Mohamed Elkashlan
  - Ahmed Fakhreldin
  - Doaa El Amrousy
- PubMed: 38568244
- DOI: 10.1007/s00431-024-05534-2
8 Insights on
- Reduced Creatine Kinase Level
- High evidence
- Clinical
L-carnitine group had significantly lower post-operative level of ... myocardial injury markers (CK-MB and troponin I)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
50 mg/kg/day once daily for 1 month before cardiac surgery
l-carnitine downregulate the muscle wasting effect of glucocorticoids in pemphigus patient: A randomized double-blind placebo-controlled study.
- 2023-04
- RCT
- Physiological reports 11(8)
- - Zeinab Noormohammadi
  - Hana Arghavani
  - Mohammadhasan Javanbakht
  - Maryam Daneshpazhooh
  - Mahmood Jalili
- PubMed: 37078370
- DOI: 10.14814/phy2.15657
6 Insights on
- Reduced Creatine Kinase Level
- High evidence
- Clinical
there were no significant inter-group differences in IGF-1 and CK levels;
Effect
Neutral
Effect size
Small
Significant
No
Dose
2 g/d