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Evidence-Based Supplement Research
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L-Carnitine and Reduced High-Sensitivity C-Reactive Protein Level

Research synthesisLow evidenceSmall effect3 studies · 1 beneficial · 2 neutral · 0 harmful

Across 3 studies, 1 reported a beneficial moderate-sized effect on reducing high-sensitivity C-reactive protein (hs-CRP), while 2 found neutral (non-significant) small effects. The evidence base is small and preliminary, with the most-studied populations being clinical (obese patients and children on hemodialysis). Median study duration was 63 days (8-9 weeks), though effects were inconsistently observed.

  • Studied populations: obese patients, children on hemodialysis, hemodialysis patients

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. The single beneficial study was observational (low evidence quality), whereas the two neutral findings came from RCTs.

Generated Jul 15, 2026
Doses used in studies
  • mg/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study
  • mg/kg/day: 50 (median 50, IQR 50–50) — 1 study
Time to effect
Median: 9 weeks · IQR 8.5 weeks–9.5 weeks · Range 8 weeks–10 weeks — Reported in 2 of 3 studies
3 of 3 papers
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