L-Carnitine and Reduced Migraine Frequency

• The effects of concurrent alpha-linolenic acid, L-carnitine supplementation on clinical symptoms, mental health, and quality of life in women with migraine: a randomized, triple-blind, placebo-controlled trial.

  • 2025-03-13
  • RCT · n = 80
  • Nutrition journal 24(1)
  • • Sahar Golpour-Hamedani
    • Mohammad Bagherniya
    • Fariborz Khorvash
    • Awat Feizi
    • Manoj Sharma
    • Gholamreza Askari

  • PubMed: 40082970
  • DOI: 10.1186/s12937-025-01107-7

  7 Insights on

  • Reduced Migraine Frequency

  • High evidence
  • Clinical

  The intervention group demonstrated a significant reduction in migraine frequency (-2.96; 95% CI (-3.48, -2.45) vs -0.07; 95% CI (-0.68, 0.53), P < 0.001)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  500 mg/day

• Investigating the effects of co-supplementation with alpha-linolenic acid and L-carnitine on inflammatory status, oxidative stress, clinical symptoms, mental health and quality of life in women with migraine: a protocol for a randomized, triple-blind, placebo-controlled trial.

  • 2024-10-08
  • RCT · n = 80
  • Trials 25(1)
  • • Sahar Golpour-Hamedani
    • Mohammad Bagherniy
    • Fariborz Khorvash
    • Awat Feizi
    • Manoj Sharma
    • Gholamreza Askari

  • PubMed: 39380085
  • DOI: 10.1186/s13063-024-08500-3

  11 Insights on

  • Reduced Migraine Frequency

  • High evidence
  • Clinical

  The primary outcomes include changes in clinical symptoms of migraine, including frequency, severity, and duration of attacks

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  500 mg/day