Best Supplements for Reduced Migraine Frequency
Ranked by research evidence. Compare 9 supplements across 15 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence4 studies
Across 4 meta-analyses and systematic reviews, all reported beneficial effects of Vitamin B2 (riboflavin) on reducing migraine frequency, with effect sizes ranging from moderate to large. All 4 findings were statistically significant. The most studied dose was 400 mg/day, and effects were observed in both pediatric and adult populations; median study duration was 90 days (based on one study).
Dose: 400 mg/day
9 supplements
- ModerateVitamin B2Across 4 meta-analyses and systematic reviews, all reported beneficial effects of Vitamin B2 (riboflavin) on reducing migraine frequency, with effect sizes ranging from moderate to large. All 4 findings were statistically significant. The most studied dose was 400 mg/day, and effects were observed in both pediatric and adult populations; median study duration was 90 days (based on one study). · Dose: 400 mg/day4 beneficial4 studies