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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin B2 and Reduced Migraine Frequency

Research synthesisModerate evidenceMixed effect size4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 meta-analyses and systematic reviews, all reported beneficial effects of Vitamin B2 (riboflavin) on reducing migraine frequency, with effect sizes ranging from moderate to large. All 4 findings were statistically significant. The most studied dose was 400 mg/day, and effects were observed in both pediatric and adult populations; median study duration was 90 days (based on one study).

  • Effective dose range: 400 mg/day
  • Studied populations: pediatric patients and adults with migraine

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The evidence base consists of 4 review-level papers rather than primary trials, and effect sizes varied from moderate to large across studies, with the highest-quality meta-analyses showing large effects.

Generated Jul 12, 2026
Doses used in studies
  • mg/day: 400 (median 400, IQR 400–400) — 1 study
Time to effect
Median: 3 months · IQR 3 months–3 months · Range 3 months–3 months — Reported in 1 of 4 studies
Safety in these studies
4 of 4 papers
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