L-Carnitine and Reduced Mortality

• The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial.

  • 2024-03-06
  • RCT · n = 60
  • Nutrition journal 23(1)
  • • Mahdi Keshani
    • Babak Alikiaii
    • Zahra Babaei
    • Gholamreza Askari
    • Zahra Heidari
    • Manoj Sharma
    • Mohammad Bagherniya

  • PubMed: 38444016
  • DOI: 10.1186/s12937-024-00934-4

  9 Insights on

  • Reduced Mortality

  • High evidence
  • Clinical

  The 28-day mortality rate was also lower in the LC group compared with placebo (7 persons vs. 15 persons) significantly (odds ratio: 0.233, p: 0.010).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  3 g/day

• The supplementation of L-carnitine in critically ill patients with sepsis: a systematic review and meta-analysis of randomized controlled trials.

  • 2024-10-05
  • Meta-Analysis · n = 356
  • European journal of medical research 29(1)
  • • Chang Meng
    • Yudan Ma
    • Ning Fu
    • Jie Li
    • Biao Sun
    • Zhichao Li
    • Qing Wang
    • Peng Liu

  • PubMed: 39367436
  • DOI: 10.1186/s40001-024-02087-w

  1 Insight on

  • Reduced Mortality

  • High evidence
  • Clinical

  And there was no significant effect on 12-month mortality (RR: 0.72; 95% CI 0.47-1.11; I2 = 0%; P = 0.14).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No