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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Carnosine and Improved Memory Function

Doses used in studies

g/day: 2 (median 2, IQR 2–2) — 1 study
mg/day: 400–800 (median 600, IQR 400–800) — 1 study

Time to effect

Median: 4.3 months · IQR 3.7 months–5 months · Range 3 months–5.6 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityIncreased risk30% vs 14%
The carnosine group reported more adverse events (30%) compared with the placebo group (14%).
from: A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improv
laboratory indicesReported
Laboratory indices remained within acceptable ranges.
from: A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improv

2 of 2 papers

Cognitive and negative symptoms in schizophrenia with L-Carnosine adjuvant therapy - A randomized double-blind placebo-controlled study.
- 2023-03-22
- RCT
- Pharmacology research & perspectives 11(2)
- - Hema Tharoor
  - Sindhu Maran
  - Antra K Chandan
  - Manikandan Pari
  - Shruti Rao
  - Jothilakshmi Durairaj
- PubMed: 36946070
- DOI: 10.1002/prp2.1074
4 Insights on
- Improved Memory Function
- High evidence
- Clinical
Secondary outcome measures were done to assess the improvement in cognitive symptoms (executive function, attention, and memory) at 24 weeks using subtests of NIMHANS cognitive battery.
Effect
Neutral
Effect size
Small
Significant
No
Dose
400 mg/day for first 3 months, then 800 mg/day from week 13 to week 24
A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophrenia.
- 2012-12
- RCT
- Schizophrenia research 142(1-3)
- - K N Roy Chengappa
  - Scott R Turkin
  - Susan DeSanti
  - Christopher R Bowie
  - Jaspreet S Brar
  - Patricia J Schlicht
  - Sherry L Murphy
  - Michelle L Hetrick
  - Robert Bilder
  - David Fleet
- PubMed: 23099060
- DOI: 10.1016/j.schres.2012.10.001
11 Insights on
- Improved Memory Function
- High evidence
- Clinical
Other cognitive tests showed no significant differences between treatments
Effect
Neutral
Effect size
Small
Significant
No
Dose
2 g/day