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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Carnosine and Increased Antioxidant Enzyme Levels

Doses used in studies

g/day: 2–4 (median 3, IQR 2.5–3.5) — 2 studies

Time to effect

Median: 5 weeks · IQR 3.5 weeks–6.5 weeks · Range 2 weeks–8 weeks — Reported in 2 of 2 studies

2 of 2 papersPopulation:

Influence of l-carnosine on pro-antioxidant status in elite kayakers and canoeists.
- 2014-12
- RCT
- Acta physiologica Hungarica 101(4)
- - Malgorzata Slowinska-Lisowska
  - A Zembron-Lacny
  - M Rynkiewicz
  - T Rynkiewicz
  - W Kopec
- PubMed: 25201708
- DOI: 10.1556/aphysiol.101.2014.008
8 Insights on
- Increased Antioxidant Enzyme Levels
- High evidence
- Athletes
it significantly attenuated exercise-induced glutathione loss, reduced oxidation/nitration markers concentration and SOD activity
Effect
Neutral
Effect size
Small
Significant
No
Dose
4 g/d for 14 days
Dietary supplementation with L-carnosine improves patient-reported outcomes, autonomic nervous system performance, and brain metabolism in 3 adult patients with multiple sclerosis.
- 2020-12
- Clinical Trial
- Nutrition research (New York, N.Y.) 84
- - Dragana Zanini
  - Tatjana Jezdimirovic
  - Valdemar Stajer
  - Jelena Ostojic
  - Nebojsa Maksimovic
  - Sergej M Ostojic
- PubMed: 33189432
- DOI: 10.1016/j.nutres.2020.09.008
9 Insights on
- Increased Antioxidant Enzyme Levels
- Moderate evidence
- Clinical
An increase in serum total antioxidant capacity (TAC) was found at 8-week follow-up in all patients (from 4.6 to 49.6%)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
2 g/day