L-Carnosine and Reduced Depression Symptoms

Doses used in studies

g/day: 2 (median 2, IQR 2–2) — 1 study
mg/day: 800 (median 800, IQR 800–800) — 1 study

Time to effect

Median: 7 weeks · IQR 6.5 weeks–7.5 weeks · Range 6 weeks–8 weeks — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityNo significant difference
There was no significant difference between the two groups in baseline parameters and frequency of side effects.
from: L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind,
Overall tolerabilityNo significant difference
Frequency of other side effects was not significantly different between the two groups.
from: L-carnosine as an add-on to risperidone for treatment of negative symptoms in patients wit
extrapyramidal symptomsNo significant difference
Both groups demonstrated a constant ESRS score during the trial course.
from: L-carnosine as an add-on to risperidone for treatment of negative symptoms in patients wit

2 of 2 papers

L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind, placebo-controlled trial.
- 2020-04
- RCT
- Journal of affective disorders 267
- - Behin Araminia
  - Mohammadreza Shalbafan
  - Amirhosein Mortezaei
  - Elham Shirazi
  - Salomeh Ghaffari
  - Erfan Sahebolzamani
  - Seyyed Hosein Mortazavi
  - Behnam Shariati
  - Mehrdad Eftekhar Ardebili
  - Ali Aqamolaei
  - Sina Naderi
  - Shahin Akhondzadeh
- PubMed: 32063564
- DOI: 10.1016/j.jad.2020.02.020
3 Insights on
- Reduced Depression Symptoms
- High evidence
- Clinical
General linear model repeated measure showed significant difference for time × treatment on HAM-D score [F = 3.17, df = 2.39, p-value = 0.03]. Significantly greater improvement was detected in HAM-D score of the L-Carnosine group compared with the placebo group from baseline to weeks 2, 4 and 6 [Ps = 0.013, 0.028 and 0.023; respectively].
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
400 mg twice daily
L-carnosine as an add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: A double-blind, randomized placebo-controlled trial.
- 2018-04
- RCT
- Psychiatry research 262
- - Alireza Ghajar
  - Mohammad-Reza Khoaie-Ardakani
  - Zahara Shahmoradi
  - Amir-Reza Alavi
  - Mohsen Afarideh
  - Mohammad-Reza Shalbafan
  - Maryam Ghazizadeh-Hashemi
  - Shahin Akhondzadeh
- PubMed: 29427913
- DOI: 10.1016/j.psychres.2018.02.012
7 Insights on
- Reduced Depression Symptoms
- High evidence
- Clinical
HDRS scores and its changes did not differ between the two groups.
Effect
Neutral
Effect size
Small
Significant
No
Dose
2 gr/day in two divided doses

L-Carnosine and Reduced Depression Symptoms

L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind, placebo-controlled trial.

L-carnosine as an add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: A double-blind, randomized placebo-controlled trial.