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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Citrulline and Increased Lean Mass

Doses used in studies

g/day: 10 (median 10, IQR 10–10) — 1 study

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 2 studies

2 of 2 papersPopulation:

Combined L-Citrulline Supplementation and Slow Velocity Low-Intensity Resistance Training Improves Leg Endothelial Function, Lean Mass, and Strength in Hypertensive Postmenopausal Women.
- 2022-12-23
- RCT · n = 13
- Nutrients 15(1)
- - Yejin Kang
  - Katherine N Dillon
  - Mauricio A Martinez
  - Arun Maharaj
  - Stephen M Fischer
  - Arturo Figueroa
- PubMed: 36615732
- DOI: 10.3390/nu15010074
3 Insights on
- Increased Lean Mass
- High evidence
- Rigorous Journal
- Clinical
Leg LM improved after CIT + SVLIRT compared to PL + SVLIRT (Δ0.49 ± 0.15 kg vs. Δ0.07 ± 0.12 kg, p < 0.05).
Effect
Neutral
Effect size
Small
Significant
Yes
Dose
10 g/day
Synergistic effect of long-term L-citruline supplementation combined with exercise on body composition in adults: A systematic review and meta-analysis of randomized controlled trials.
- 2026-06
- Review
- Complementary therapies in medicine 98
- - Weizheng Wang
  - Shanshan Cai
  - Kang Liu
  - Ping Luo
- PubMed: 41786156
- DOI: 10.1016/j.ctim.2026.103339
6 Insights on
- Increased Lean Mass
- Low evidence
- Adults
no significant effects were observed on ... TLM (SMD = -0.02, 95% CI: -0.23-0.19, P = 0.83)
Effect
Neutral
Effect size
Small
Significant
No