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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Citrulline and Reduced Mean Arterial Pressure

Doses used in studies

g/day: 10 (median 10, IQR 10–10) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
Across all studies, no adverse effects related to citrulline supplementation were reported.
from: Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscu

2 of 2 papersPopulation:

Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.
- 2026-01-26
- Systematic Review
- BMC women's health 26(1)
- - Hossein Bahari
  - Elmira Ramezani
  - Mahsa Malekahmadi
- PubMed: 41588439
- DOI: 10.1186/s12905-026-04277-6
9 Insights on
- Reduced Mean Arterial Pressure
- High evidence
- Elderly
most showing reductions in systolic blood pressure and mean arterial pressure
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
not specified in abstract
Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.
- 2022-10-20
- RCT
- Nutrients 14(20)
- - Arun Maharaj
  - Stephen M Fischer
  - Katherine N Dillon
  - Yejin Kang
  - Mauricio A Martinez
  - Arturo Figueroa
- PubMed: 36297080
- DOI: 10.3390/nu14204396
5 Insights on
- Reduced Mean Arterial Pressure
- High evidence
- Rigorous Journal
- Clinical
... and mean arterial pressure (Δ−2 ± 4 vs. Δ2 ± 6 mmHg, p = 0.04) were significantly decreased after 4 weeks of L-CIT compared to PL.
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
10 g