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Evidence-Based Supplement Research
Evidence-Based Supplement Research

Best Supplements for Reduced Mean Arterial Pressure

Ranked by research evidence. Compare 11 supplements across 16 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.

Top picks by evidence

  • Moderate evidence5 studies

    Across 5 randomized controlled trials, all 5 reported small beneficial effects of red grape (primarily grape seed extract) supplementation on reducing mean arterial pressure (MAP). Effects were observed in short-term studies (median duration 7 days) and in populations including men with prehypertension, overweight/obese individuals, and NAFLD patients. The most commonly tested doses were 300 mg (single dose) and 520 mg/day, though dose reporting was inconsistent.

11 supplements
  • ModerateRed GrapeAcross 5 randomized controlled trials, all 5 reported small beneficial effects of red grape (primarily grape seed extract) supplementation on reducing mean arterial pressure (MAP). Effects were observed in short-term studies (median duration 7 days) and in populations including men with prehypertension, overweight/obese individuals, and NAFLD patients. The most commonly tested doses were 300 mg (single dose) and 520 mg/day, though dose reporting was inconsistent.5 beneficial5 studies
  • L-Citrulline2 beneficial2 studies
  • Black Cumin1 beneficial1 study
  • Carnosine1 beneficial1 study
  • Honey1 neutral1 study
  • Coffee1 neutral1 study
  • L-Arginine1 neutral1 study
  • Lemon Balm1 neutral1 study
  • Red Beet1 neutral1 study
  • Berberine1 neutral1 study
  • tart cherry1 neutral1 study
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