L-Glutamine and Increased Hemoglobin Levels

• The GLOBE Trial: Efficacy and Safety of L-Glutamine Plus Hydroxyurea Versus Hydroxyurea Alone in Sickle Cell Anemia - A Double-Blind, Randomized Study

  • 2026-02-10
  • RCT · n = 53
  • Turkish journal of haematology : official journal of Turkish Society of Haematology 43(2)
  • • Nader Shakibazad
    • Moslem Momenzadeh
    • Batool Amiri
    • Marzieh Mahmoodi
    • Mani Ramzi

  • PubMed: 41664386
  • DOI: 10.4274/tjh.galenos.2026.09709

  5 Insights on

  • Increased Hemoglobin Levels

  • High evidence
  • Clinical

  greater fetal Hb increases (+6.2% vs. +1.6%; p<0.001)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  not specified in abstract